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Gas gangrene is another clostridial infection produced by the introduction of anaerobic organisms into a wound. Within a few days, severe pain develops in the injured part. Below this point the tissue becomes cold and swollen and eventually develops into gangrene. The wound drains a watery brown material, which may have a sweet odor.

Immediately opening the wound to permit adequate oxygen entrance is important, associated with hydrogen peroxide irrigation and therapies that draw fluid from the wound. This may include the use of dry sucrose (table sugar or honey), increased oxygen, and rarely in more serious cases amputation to prevent death from this severe complication. The most reliable protection against gas gangrene is thorough cleansing of the wound. Avoiding unsterile surgical procedures (septic abortion) prolonged labor, or operative interference with pregnancy can also help prevent these infections.

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